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doi: 10.1016/j.yfrne.2007.08.001

S.SelvarajS.VeroneseM.RizzoG.BertoldoA.OwenD

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One is a tetrahedral geometry with three nitrogen atoms and one oxygen atom from three histidine ligands, imitating the active site of CA, and the other is a distorted trigonal bipyramidal geometry also coordinated by the histidine ligands

Firstly, while microneedle technology is more advanced in skin and ocular drug delivery, its application in liver disease treatment requires further research, which undoubtedly increases the complexity of clinical translation for liver diseases