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Over a 10-dose vial cycle, dead space can waste 0.5 to 1.75mg

Bottom line Existing evidence comparing oral with IM vitamin B12 is suboptimal

Slow or Non-Responders: Not everyone experiences dramatic benefits

Overall, the pathogenesis of vitamin B12 deficiency is multifaceted, involving impaired DNA synthesis, neurological dysfunction, and various underlying causes leading to inadequate B12 levels
