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The following types of targeted therapy are used or being studied in the treatment of melanoma: Signal transduction inhibitor therapy: Signal transduction inhibitors block signals that are passed from one molecule to another inside a cell

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In the case of NTRK (1 and 3), expression is usually so intense that moderate, weak, or patchy expression should be considered doubtful because some isoforms of NTRK are expressed in healthy melanocytes and NTRK can be expressed in non-Spitz melanocytic tumors (e.g., blue nevus and deep penetrating nevus) owing to overexpression of ALK via other molecular mechanisms

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