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J Biol Chem 244(22):60496055

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A mutant 2 AR in which all the phosphorylation sites are altered, such that there is no agonist-induced phosphorylation, shows impaired ubiquitination as well as significantly reduced -arrestin interaction [70, 80]

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Phosphorylation was first discovered to be of major importance in vertebrate circadian clock regulation in the tau mutation in Syrian hamsters, where a lowered rate of CKI-dependent phosphorylation of Per2 occurred, resulting in shortened period of free running rhythms (Lowrey et al., 2000)

However, the association between MTHFD2L, which can use either NAD + or NADP + for dehydrogenase activity, and tumors remains to be investigated