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FIGURE 5 Age- and sex-dependent effects of pomegranate extract on TMAO response Although the overall effect of the pomegranate extract on plasma TMAO AUC was null ( P = 0.945), we observed that the participants with increasing TMAO were older (Figure 6A), and in particular the three oldest women ( n = 3

Recently, it was reported that the expression of pro-neuroinflammatory genes such as inducible nitric oxide synthase, cyclooxygenase-2, signal transducer, an activator of transcription 1, and nuclear factor-B, was significantly downregulated in a dose-independent manner following treatment with Madecassoside [140]

Author information Authors and Affiliations CHU Bordeaux, Service dOphtalmologie, Bordeaux, France Jean-Franois Korobelnik University of Bordeaux, INSERM, BPH, UMR1219, Bordeaux, France Jean-Franois Korobelnik Bayer Consumer Care AG, Basel, Switzerland Sergio Leal Department of Medicine - Ophthalmology, University of Udine, Udine, Italy Paolo Lanzetta Istituto Europeo di Microchirurgia Oculare - IEMO, Udine, Italy Paolo Lanzetta Centro Mdico Reumatolgico Organizacin Mdica de Investigacin S.A

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Guzzoni V, Ribeiro MBT, Lopes GN, et al