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Transport across the BBB may be facilitated by sodium-dependent transport system [76] or converting cysteine to cystine, which is subsequently exchanged with intracellular glutamate via the cystine-glutamate antiporter, and reduced back to cysteine for GSH production [115, 116]

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Int J Mol Med 19:16572 Rushworth SA, Ogborne RM, Charalambos CA, OConnell MA (2006) Role of protein kinase C in curcumin-induced antioxidant response element-mediated gene expression in human monocytes

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The oxidative damage to proteins can be induced in part by Cd, potentially due to a decrease in GPX activity

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