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BP blood pressure, exp experiment, ICAM-1 intercellular adhesion molecule-1, ND not determined, PBMC peripheral blood mononuclear cells, SD sleep deprivation, TSD total sleep deprivation, VCAM-1 vascular cell adhesion molecule-1, yrs years, significant increase, significant decrease, = no significant change

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These are the early and mid-stage signs that your dog would benefit from senior dog supplements: Stiffness when rising , especially after sleep or rest Reluctance to climb stairs or jump onto furniture they previously managed easily Dull, dry, or thinning coat despite a consistent diet Digestive irregularity : frequent loose stools, gas, or inconsistent appetite Increased frequency of minor infections or slower recovery from illness Reduced energy or enthusiasm for activities they used to love Visible muscle loss , particularly over the hindquarters or topline If you're noticing two or more of these, it's worth talking to your veterinarian and starting a targeted supplement regimen