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It binds to specific strychnine-sensitive glycine receptors (GlyRs), opening chloride ion channels that allow negatively charged ions to flood into the neuron, thereby hyperpolarizing it

Acknowledgements We thank the core facilities of the Flow Cytometry Core, Metabolomics Core, and the Laboratory of Animal Research at the Convergence Medicine Research Center (CREDIT), Asan Medical Center, for the use of their shared equipment, services, and expertize

We examined a wide range of preclinical modelsfrom in vitro systems and classical toxin- and immune-mediated paradigms to humanized mice, large animal models and patient-derived 3D CNS organoidshighlighting their complementary roles in mechanistic discovery and therapeutic testing