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Conclusions In general, our study indicated that chronic ethanol exposure may cause exacerbated continuously deteriorating cognitive impairment and neuroinflammatory damage in APP/PS1 mice compared to WT mice

doi: 10.1016/j.cbi.2007.06.038 229 WuH.ZhaoX.HochreinS

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Insulin regulates the unfolded protein response in human adipose tissue

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A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification