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Recent studies have also demonstrated that the transcriptional coregulator DOR (diabetes- and obesity-related gene) in mature oligodendrocytes promotes remyelination in aged mice by activating and modulating -KG metabolism, thereby mitigating age-associated decreases in remyelination capacity [129]

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Recommendations: Do not take more than the recommended dose

In a similar study in ESRD patients also receiving 20 mg/kg CARNITOR 3 times per week after hemodialysis, 12- and 24-week mean pre-dialysis (trough) levocarnitine concentrations were 189 (N=25) and 243 (N=23) mol/L, respectively