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This issue could only arise from incorrect administration

Their results showed an improvement in mortality and liver functional tests (serum transaminases, lactate dehydrogenase, and international normalized ratio) in the NAC group starting 24 h after the therapy commenced and lasting for the duration of the two-week follow-up

This procedure typically resulted in 30-40% of becoming monoglutathionylated with less than 10% diglutathionylated

To be able to identify low-risk BER thresholds that would be protective for a range of chemicals and human exposure scenarios would require additional work to characterize further the uncertainties in both the exposure and toxicodynamic parts of our NAM toolbox, as discussed below

Soares AR, Gildawie KR, Honeycutt JA, Brenhouse HC

Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, et al