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30 Substitution Reactions of L-Carnitine The carboxyl group on L-carnitine can be reduced to a hydroxyl group using reducing agents

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In addition to OCTN2, organic cation transporter 1 (OCT1, SLC22A1) can also promote the hepatic efflux of acetylcarnitine and contribute to the plasma acetylcarnitine pool [60]

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Adicionalmente, la sibutramina produce un aumento de la frecuencia cardaca y la presin sangunea, que pueden provocar arritmias, cardiopatas isqumicas y accidentes vasculares graves en algunos pacientes