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Clinical pharmacokinetic studies have demonstrated that bromelain significantly enhances the intestinal absorption of quercetin

Germ-free mice had a higher colonic expression of claudin-1 and occludin as compared with conventional mice, with lower paracellular uptake of a standard probe, suggesting that commensal microbiota controls colonic TJs proteins and paracellular permeability (190)

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Bellon M, Nicot C (2017) Telomere dynamics in immune senescence and exhaustion triggered by chronic viral infection Viruses 9(10): 289