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The Reassessment, which revisited this issue given the current evidence and a different draft classification scheme, characterized TCDD as carcinogenic to humans. In 2005, after completion of the Reassessment, EPA further revised its cancer guidelines

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55 The newly synthesized BMP-7, but not BMP-4, activates p-Smad1/5, subsequently inducing the expression of the chondrocyte-specific transcription factor Sox9

doi: 10.1152/ajpcell.1990.258.1.C77