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Pachymic acid (PA), a lanolin-type triterpenoid, demonstrates ferroptosis-inhibitory properties by reducing MDA, ROS, and Fe 2 levels while upregulating GSH, SLC7A11, and GPX4, thereby alleviating MIRI [92]

doi: 10.1186/s13075-014-0432-1 74 MatasJGarcaCPobleteDVernalROrtloffALuque-CamposNet al

Total antioxidant and glutathione levels have been shown to be lower within the plasma of non-medicated, medicated, first-episode and chronic schizophrenia patients ( Results from in vivo MRS studies of glutamate/glutamine concentrations in schizophrenia, whilst inconsistent, have highlighted that sub-grouping patients on residual schizophrenia (long-term negative symptoms/impairments) revealed reduced, highly correlated, GSH, glutamate and glutamine concentrations in the ACC ( It has been suggested that, in schizophrenia, redox dysregulation and subsequent oxidative stress may be limited to a specific subgroup representing ~1 third of patients ( Genetic Studies Genome wide association studies have shown an association between gene polymorphisms for oxidative stress and schizophrenia ( Animal Models Higher levels of reactive species within mitochondria have been found in the brains of ketamine-induced rat models of schizophrenia compared to wild-type controls ( Evidence of redox dysregulation is seen in other common neurodevelopmental animal models of schizophrenia

10.1164/rccm.200806-851OC Summary Keywords glutathione peroxidase, redox balance, oxidative stress, inflammation, iron death Citation Pei J, Pan X, Wei G and Hua Y (2023) Research progress of glutathione peroxidase family (GPX) in redoxidation

We hypothesize that GSH may promote R

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