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However, upon reperfusion, the role of autophagy becomes more complex and context-dependent

Oxidative stress and alterations in the GSH metabolism of the brain have been connected with many neurological and neurodegenerative diseases as recently summarized (Asanuma and Miyazaki 2021

Data availability The experimental data used to support the findings of this study are available from the corresponding author upon request

In MCAS, mast cells inappropriately degranulate, releasing a flood of histamine, tryptase, and inflammatory cytokines in response to minor triggers

However, large molecules, hydrophilic compounds, and many therapeutic agents, such as antibodydrug conjugate (ADC), are excluded, limiting the ability of systemic treatment to reach the brain