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Their study found multiple IDO2 gene mutations in ME/CFS patients, correlating with symptom severity
The TCA cycle is not only involved in catabolism, but is also critical for the biosynthesis of a number of molecules including amino acids, lipids, and nucleotide bases (Roberts et al., 1953)

A study conducted by Lee et al
The work still happens naturally, but with better support behind it

However, cells with a YAP/TAZ knockdown acted similarly to those grown on the compliant matrices
