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However, verapamils dual effects on drug metabolism, particularly its inhibition of CYP3A activity, raise concerns about potential interactions with essential TB drugs like rifampin, which is known to induce CYP3A enzymes [87]

We then evaluated the capacity of TF to protect against ferroptotic cell death, which is characterized by intracellular iron accumulation and an imbalance of the antioxidant system

Curcumin modulates photoaging through concentration-dependent crosstalk between autophagy regulators and stress-response pathways

In vitro alkaline comet assay For protocol optimization and to gain an initial impression of the genotoxic potential of NAs in the selected liver models (PCLiS, PHH, PRH and HepG2 cells in the presence of rat or hamster S9-mix), the test systems were treated with NDMA as one of the most potent mutagenic and carcinogenic NAs and subjected to the in vitro alkaline comet assay

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Arch Dis Child 74(6):542545 Jaeken J, Detheux M, Fryns JP, Collet JF, Alliet P, Van Schaftingen E (1997) Phosphoserine phosphatase deficiency in a patient with Williams syndrome