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In summary, modulating the surface charge of nanoparticles can improve their ability to deliver drugs into the CNS via the endogenous transport mechanism of the BBB

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This means that if you take a mega dose, only the amount that can be absorbed in the intestine makes it into your bloodstream

[DOI] [PMC free article] [PubMed] [Google Scholar] Algothmi K.M., Mahasneh Z.M., Abdelnour S.A., Khalaf Q.A., Noreldin A.E., Barkat R.A., Khalifa N.E., Khafaga A.F., Tellez-Isaias G., Alqhtani A.H., Swelum A.A., Abd El-Hack M.E

Association of high-risk human papillomavirus infection duration and cervical lesions with vaginal microbiota composition