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G-protein-mediated signaling can also contribute to both therapeutic and adverse outcomes, and differences in intrinsic efficacy and receptor reserve can give rise to apparent pathway bias without true pathway-selective engagement

provided clinical expertise and contributed to final manuscript editing

Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, et al

When used concurrently with insulin or insulin secretagogues such as sulfonylureas or meglitinides, the risk of hypoglycemia may be increased, particularly during the initiation of therapy or following dose escalations

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J Clin Neuromuscul Dis 2010