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1), the NH proton of the hydrazone group was observed at 10.41 ppm [35, 39], while the peaks of the NH protons in the thiosemicarbazone group (NH and -NH 2 ) were observed at 12.99 and 13.37 ppm [41]

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The chapter also reviews other mechanisms involved in the long-term effects of opioids, such as neuroplasticity, changes in neurotransmitter release, activation of anti-opioid systems, and neuroinflammation

eNOS , endothelial NO synthase