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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Noblanc A., Peltier M., Damon-Soubeyrand C., Kerchkove N., Chabory E., Vernet P., Saez F., Cadet R., Janny L., Pons-Rejraji H., et al

10.1097/00002030-199208000-00008 AIDS 38 DeffieuM.Bhatia-KissovaI.SalinB.GalinierA.ManonS.CamougrandN

doi: 10.1186/cc6887

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While rats receiving the same dose, i.e., 15.6 /mcg/kg bodyweight of fentanyl (0.3MAC), for 6 consecutive days showed increase of transaminases, mainly GPT, also known as ALT, after repeated injections of fentanyl, with no evidence of liver necrosis ( Still, to make matters more complicated, all the anesthetics have long ago been hypothesized that could affect the liver through perturbing the permeability of liposome membranes and consequently impairing cell functions ( In eliciting hepatotoxicity, the role of the liver detoxification system is expected to be highlighted

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