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[DOI] [PMC free article] [PubMed] [Google Scholar] 151.Auyeung B., Lombardo M., Heinrichs M., Chakrabarti B., Sule A., Deakin J.B., Bethlehem R., Dickens L., Mooney N., Sipple J.A.N., et al

Fat stored around internal organs in the abdominal cavity, associated with increased metabolic and cardiovascular disease risk compared to subcutaneous fat stored under the skin

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However, there is only one approved drug, setmelanotide for POMC-LEPR deficiency [10], and there is no treatment for other POMC-MC4R pathway-deficient diseases, such as POMC-null, MSH-deficiency, and patients with PWS with obesity