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5-Amino-1MQ (5-Amino-1-methylquinolinium iodide, CAS 42464-96-0) is a synthetic small-molecule quaternary quinolinium compound that functions as a selective substrate site-targeting inhibitor of nicotinamide N-methyltransferase (NNMT)

This increase in NAD availability improves metabolic flexibility , enabling the body to switch between carbohydrate and fat fuel sources more efficiently

European Journal of Pharmacology , 570(13), 212221

Persistent or worsening symptoms despite supplementation warrant medical review

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While Semax has clinical history in Russia, the English-language human evidence base remains limited , so it should be approached with clear expectations, careful screening, and clinician-guided riskbenefit review