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Concurrently, a significant increase in NADH/NAD + ratio ( P = 0.0002) was observed (Figure 6C), suggesting that the observed metabolic disruptions were a result of oxidative stress, potentially as a compensatory mechanism to sustain energy production and redox homeostasis in the absence of GR

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Acknowledgments The authors acknowledge the use of BioRender to create schematic representations in Figures 1 3

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Additionally, B12 injections can aid in the production of red blood cells, promoting healthy circulation and helping to prevent anemia, which supports cardiovascular health and mental clarity