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This is not an assumption or a theoretical claim

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Because of this targeted action, researchers are now studying peptides for stem cell activationa promising direction where peptides enhance the regenerative potential of stem cells without replacing them

But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create

JAGS 2022;70(11):32503259

Unlike fat-soluble vitamins (A, D, E, and K) that can build up, B12 has a strong safety record and toxicity is rare