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Coagulation Abnormalities Methimazole and to a lesser extent propylthiouracil (PTU) inhibit vitamin Kdependent clotting factor activation (-carboxylation) and epoxide reductase (necessary for vitamin K recycling, and the same enzyme targeted by warfarin) at high concentrations

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Discontinue use if irritation occurs

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doi: 10.1038/s41392-022-01014-x 94 LiK.LiA.MeiY.ZhaoJ.ZhouQ.LiY.et al