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In this scenario, with some sacrifice on warhead reactivity (k inact ), a high overall efficacy (k eff ) can only be achieved through optimizing for the non-covalent binding contribution (reflected by inactivation constant K I ) [107]

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This may be a consequence of the scale of correlative analysis of this set of methods relative to the ROI compared to attenuation and BSC-based methods, which may be more robust for larger ROIs