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Conversely, overfeeding increases intra-portal insulin levels that enhances hepatic GH sensitivity to a degree where relatively low GH secretion is sufficient to maintain ambient hepatic IGF-I synthesis and secretion, and normal circulating IGF-I levels ( Figure 1 This review summarizes how changes in hepatic exposure to intra-portal insulin in health and disease states modulates the GH/IGF-I axis

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Electrical Vagus Nerve Stimulation Decreases Food Consumption and Weight Gain in Rats Fed a HighFat Diet. Journal of Physiology and Pharmacology 62: 637

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CSE utilizes cystathionine generated by CBS to generate cysteine, a semiessential amino acid