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Notably, SCFAs act as critical signaling metabolites that activate G-proteincoupled receptors (GPCRs), thereby suppressing pro-inflammatory cytokine production and promoting regulatory T-cell expansion within the colonic mucosa (301)
10.1093/toxres/tfaa009 3 Abd RaniN
At the immune cell level, melatonin enhances CD4 + /CD8 + T cell proliferation and antigen responsiveness, modulates the Treg/Th1/Th2 balance, promotes macrophage polarization toward the anti-inflammatory M2 phenotype, and augments NK cell cytotoxicity

It may carry risks, especially when used without medical oversight

[DOI] [PubMed] [Google Scholar] 94.Shibata S, Tominaga K, Watanabe S

Schneider, Anne-Fleur E
