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FIGURE 2 The genus Akkermansia is consistently enriched in human PD patients versus healthy controls, and the data corroborate recent findings in an A53T -synuclein Tg non-human primate model

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However, in the striatum, which is located in the subcortical forebrain, insulin influences dopamine reuptake and release, with IR opposing these effects, impacting neuronal excitatory projections [90]

This 24-week ramp to 1.0mg takes 50% longer than the standard 12-week path but dramatically reduces the incidence of GI side effects

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