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doi: 10.3389/fbioe.2020.00495 190 GopalTKumarNPerriotte-OlsonCCaseyCADonohueTMHarrisENet al

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Low doses of GH administration to 22-month-old Wistar rats for 8 weeks increased circulating IGF-1 levels, enhanced the synthesis of mitochondrial proteins and antioxidant enzyme activities (catalase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase (G6PDH)), and reduced oxidative damage (measured by the levels of 8-OHdG) in the skeletal muscle [23]

Dehydroabietic acid promotes the expression of GSH and GPX4, reduces ROS accumulation, reduces hepatic lipid peroxidation, inhibits hepatic ferroptosis, and improves NAFLD ( 6.2.2 Pathway-specific regulation of ferroptosis and lipid accumulation Diosgenin significantly alleviates ferroptosis and ROS accumulation in HepG2 cells by regulating the ACSL4/LPCAT3/ALOX15 pathway, thereby mitigating NAFLD (Wang et al., 2025a)