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BPC-157 occupies a separate category altogether: a tissue-targeted compound with intriguing preclinical findings but a much thinner human evidence base and a more complicated regulatory picture

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This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis

This selectivity helps avoid some side effects commonly associated with HGH, such as insulin resistance or abnormal growth

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