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Katz DF, Bloom TD, BonDurant RH

Tarducci, G

Nonetheless, in a direct comparison of the reactions of lysine, histidine, serine and cysteine with a synthetic keto-epoxide analogue, only Cys adducts were detectable after 1h reaction at 37 C in physiological buffer, and Ohno and co-workers went on to identify the adducts as formed by Michael addition to the conjugated enone

10.1128/IAI.00193-16 242 ZhaoY

In normal mice, front and rear paw prints typically overlapped, showing coordinated movement, whereas gouty mice exhibited a clear separation between these prints, demonstrating altered gait patterns