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Sun and coworkers studied and compared the impact of sulfur, selenium, and carbon linkages in paclitaxel-citronellol prodrug conjugates 89 Six different paclitaxel-citronellol prodrug conjugates containing either thioether, disulfide, selenoether, diselenide, carbon or carbon-carbon bond as a spacer have been synthesized and compared in terms of their self-assembly, redox-responsivity, drug loading and release behavior

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