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Furthermore, tobacco smoke is one factor that significantly contributes to oxidative stress and, consequently, to changes in the epigenetic machinery involving methylation (Mecocci and Polidori, 2012)

PMID: 18343939

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To date, SF has proven to be the most potent activator of transcription factor (NRF2), which regulates the antioxidant response to suppress inflammation (Houghton et al ., 2016)

This is attributed to the weakening of the bodys inherent antioxidant defenses and the detrimental influence on immune system dynamics (116)