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Generally, the modulation of these processes begins with the activation of G-protein coupled receptors (GPCRs) in the somatotrophs ( Figure 2 )

PLoS One 9 , e103554 (2014)

Research suggests that phytochemicals can modulate the release of proinflammatory cytokines, such as TNF- and IL-6, and reduce oxidative stress, ultimately contributing to TBI neuroinflammation
doi:10.1016/j.fct.2020.111346

During the coagulation process necessary for serum isolation, platelets release vascular endothelial growth factor, which can significantly alter cytokine levels (190)
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