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Finally, human clinical trials have clearly demonstrated that diabetes remission can be achieved using glucose-lowering therapies and particularly strategies focused on weight loss, including bariatric surgery and, more recently, the use of highly efficient new drugs targeting the incretin system

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Enhanced GSH level was also correlated with enhanced salt tolerance in several studies

doi: 10.1371/journal.pone.0309415 51 Martnez-LpezMFLpez-GilJF

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Compared with CON, treatment with IGF-1 had no effect on Syn-IR at P5 in all analyzed regions, including the parietal and entorhinal cortexes and hippocampal subfields, whereas at P9, it was decreased in the IGF-1 group in the total cortical areas ( p = 0.032) and showed a tendency to lower IR in the hippocampus ( p = 0.07