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Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (TSPO)

In the trial-product estimand analysis (accounting for treatment adherence), reductions reached 22.7% and 2.3%, respectively, corresponding to an absolute weight loss of -21.6 kg with combination therapy

[DOI] [PubMed] [Google Scholar] Cominacini L, Garbin U, Pasini AF, Davoli A, Campagnola M, Contessi GB, Pastorino AM, Lo Cascio V

Neurosci Bull 39(9):14261438 Zalachoras I, Hollis F, Ramos-Fernndez E et al (2020) Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

This suggests the drug was engaging relevant pathways, just not sufficiently to translate to clinical benefit at this disease stage

People who inject while standing or with a bent, tensed leg consistently report more discomfort