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[22] Chelation therapy prior to heavy metal testing can artificially raise urinary heavy metal concentrations ("provoked" urine testing) and lead to inappropriate and unnecessary treatment

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Nevertheless, the glutathione used is not lost, because a special enzyme the selenium-containing glutathione reductase converts the GSSG back into two active glutathione molecules

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This reaction is more pronounced at higher concentrations, with rapid injection, in low-fat areas, and without adequate buffering with bacteriostatic saline

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