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The degree of melanin pigmentation is determined by the number and distribution of melanocytes in the basal cell layer of the oral epithelium of each anatomical region, by their melanogenic activity, by the degree of arborisation of the dendritic processes of the melanocytes, and by the number, size, and distribution of melanosomes in the melanocyte-keratinocyte unit [46]

This will enable clinicians to intervene with the right treatment strategies and prevent the evolution of the condition

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Long-term studies indicate sustained results when fat cells are dissolved and eliminated from the body through natural fat metabolism processes

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