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Figure 2 Interestingly, many of the initial studies elucidating NRF2-ARE-mediated cellular protection utilized tert -butyl hydroquinone (tBHQ), a synthetic antioxidant and inducer of the NRF2 pathway via its auto-oxidized, electrophilic form tert-butyl benzoquinone (tBQ) (Rushmore and Pickett, 1990
However, its side effects and resistance can limit its effectiveness in clinical therapy
Epidemiological evidence shows that chronic exposure to the herbicide paraquat (PQ) elevates PD risk by approximately 64% [85]
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Stroke and the immune system: from pathophysiology to new therapeutic strategies
