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It is caused by the increase of iron-dependent reactive oxygen species due to intracellular iron overload, which leads to the accumulation of lipid peroxides, thus inducing cell membrane oxidative damage, affecting the normal life process of cells, and finally promoting the process of ferroptosis

Today, clustered symptoms like tremor at rest, stiffness, slowed movement, and postural instability are classified, based upon their cause, into different categories

Zheng XT, Yu ZC, Tang JW, Cai ML, Chen YL, Yang CW et al (2020) The major photoprotective role of anthocyanins in leaves of Arabidopsis thaliana under long-term high light treatment: antioxidant or light attenuator

This can stabilize MTF-1 and increase its binding to MREs, resulting in increased MT gene expression [34, 37]