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15 SundarRBandlaATanSSHLiaoL-DKumarakulasingheNBJeyasekharanADet al

Neurogenic inflammation encompasses hyperemia, plasma protein extravasation, mediator release, and leukocyte infiltration and has been thought to contribute to a series of inflammatory diseases, including asthma and COPD

Neutrophilic inflammation occurs in both lung and GCF, where activating cytokines are produced by the underlying fibroblasts, lining the epithelium and inflammatory cells in response to microbial insult

[26] further speculate that subjects with hypersensitive mast cells may represent a unique subgroup of patients who are more likely to respond to environmental and stress triggers, precipitating or worsening ASD

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