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Levodopa remains the most effective agent for controlling motor symptoms, but its long-term use leads to motor complications, reduced efficacy, and treatment resistance ( 5.1 Levodopa and the rationale for combination therapy Levodopa, often co-administered with carbidopa to inhibit peripheral metabolism, is the gold standard for PD treatment

A pan-cancer proteogenomic atlas of PI3K/AKT/mTOR pathway alterations

Tollefson AK, Oberley-Deegan RE, Butterfield KT, et al

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Biomed Pharmacother 175:116790 Wechselberger C, Messner B, Bernhard D (2023) The role of trace elements in cardiovascular diseases