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Recently, a structure-based screening has led to the discovery of the first NAPRT activators based on 1,2-dimethylbenzimidazole scaffolds 231 , but evidence for these compounds in boosting NAD + metabolism is still lacking

Senescence-accelerated mouse-prone 8 (SAMP8) mice, a model susceptible to age-related metabolic and hepatic dysfunction, were used by Suchkov et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Maurice T., Mustafa M.H., Desrumaux C., Keller E., Naert G., Garcia-Barcelo M.D., Rodriguez Cruz Y., Garcia Rodriguez J.C