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GHRP-6 prevented this reduction and significantly increased IGF-1 abundance by nearly 386% relative to DOX alone

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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Chen L, Xu J, Zhu L, Xu P, Chang L, Han Y, Wu Q

Science (New York, N.Y.) , 365(6448), 34

Under basal conditions, NRF2 is kept inactive through binding to its negative regulator KEAP1, which is a redox-regulated substrate adaptor for the Cullin (Cul)3-RING-box protein (Rbx)1 ubiquitin ligase complex that directs NRF2 for degradation [10]

Without glutathione, cells will die at a faster rate, leading to quicker ageing