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however, unlike in OD, response may be immediate, which is not compatible with the pharmacological effect, which begins after a few days, typically peaking at 2 weeks (183, 211)

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European Journal of Pediatrics January 1991, Volume 150, Issue 3, pp 205-208 16 Sklar R

94 Under both physiological and stress conditions, chaperone proteins such as Hsp60 and mtHsp70 ensure proper protein folding while being regulated by stress-responsive transcriptional programs, including heat shock factors

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