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Conclusion: In women with EM-associated pain who met prespecified BMD loss criteria in the SPIRIT LTE, there was recovery or trend towards recovery after treatment cessation in all women who received continuous Rel-CT therapy for up to 2 years and in most women who transitioned from placebo to Rel-CT

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Following that the genomic surveillance function of p53 was seriously interfered, damaged hepatocytes can escape from p53-mediated death and respond to proliferation-related signals, which induce maintenance of mutations and transmission of these mutations from parental cells to daughter cells [108]