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The most important component of mixed function oxidases is the cytochrome P-450 since it binds to the substrate and activates oxygen

Substantially pure compositions of at least about 90 to 95% homogeneity are preferred, and 98 to 99% or more homogeneity are most preferred for pharmaceutical uses

Involvement of Hypoxia-Inducible Factor-1-Alpha in Multidrug Resistance Induced by Hypoxia in HepG2 Cells

doi:10.1071/rd14165

Singer K, Cheng W-C, Kreutz M, Ho P-C, Siska PJ

Excessive generation of NAPQI results in its robust reaction with hepatic glutathione stores and the subsequent rapid depletion of glutathione within the liver